ENIGMA Trial

Article Name: Avoidance of nitrous oxide for patients undergoing major surgery: a randomized controlled trial.

Short Citation: Anesthesiology 2007;107(2):221-31.

Article Year: 2007

Lead Author(s): Myles PS, Leslie K, Chan MT, Forbes A, Paech MJ, Peyton P, et al.

PubMed PMID: 17667565

Full Citation: Myles PS, Leslie K, Chan MT, Forbes A, Paech MJ, Peyton P, Silbert BS, Pascoe E; ENIGMA Trial Group. Avoidance of nitrous oxide for patients undergoing major surgery: a randomized controlled trial. Anesthesiology 2007;107(2):221-31.

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Authors' Conclusions: Avoidance of nitrous oxide and the concomitant increase in inspired oxygen concentration decreases the incidence of complications after major surgery, but does not significantly affect the duration of hospital stay. The routine use of nitrous oxide in patients undergoing major surgery should be questioned.

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