Short Citation: Ann Emerg Med 2014;63(5):600-607.
PubMed PMID: 24342819
Full Citation: Mal S, McLeod S, Iansavichene A, Dukelow A, Lewell M. Effect of out-of-hospital noninvasive positive-pressure support ventilation in adult patients with severe respiratory distress: a systematic review and meta-analysis. Ann Emerg Med 2014;63(5):600-607.
Organ System: Respiratory
Science Area: Pharmacology / Medical Therapy
Article Type: Meta Analysis / Systematic Review
Study Size: 632
Findings: Seven randomized controlled trials were included, with a combined total of 632 patients; 313 in the standard therapy group and 319 in the NIPPV group. In patients treated with NIPPV, the pooled estimate showed a reduction in both inhospital mortality (RR 0.58; 95% CI 0.35 to 0.95; NNT=18) and need for invasive ventilation (RR 0.37; 95% CI 0.24 to 0.58; NNT=8). There was no difference in ICU or hospital length of stay.
Authors' Conclusions: Out-of-hospital administration of NIPPV appears to be an effective therapy for adult patients with severe respiratory distress.