Mal AEM 2014 – Out-of-hospital NIV for severe respiratory distress

Short Citation: Ann Emerg Med 2014;63(5):600-607.

PubMed PMID: 24342819

Full Citation: Mal S, McLeod S, Iansavichene A, Dukelow A, Lewell M. Effect of out-of-hospital noninvasive positive-pressure support ventilation in adult patients with severe respiratory distress: a systematic review and meta-analysis. Ann Emerg Med 2014;63(5):600-607.

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Study Size: 632

Findings: Seven randomized controlled trials were included, with a combined total of 632 patients; 313 in the standard therapy group and 319 in the NIPPV group. In patients treated with NIPPV, the pooled estimate showed a reduction in both inhospital mortality (RR 0.58; 95% CI 0.35 to 0.95; NNT=18) and need for invasive ventilation (RR 0.37; 95% CI 0.24 to 0.58; NNT=8). There was no difference in ICU or hospital length of stay.

Authors' Conclusions: Out-of-hospital administration of NIPPV appears to be an effective therapy for adult patients with severe respiratory distress.

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