Article Name: Is intraoperative dexmedetomidine a new option for postoperative pain treatment? A meta-analysis of randomized controlled trials.
Short Citation: Pain. 2013 Jul;154(7):1140-9.
Article Year: 2013
Lead Author(s): Schnabel et al.
PubMed PMID: 23706726
Full Citation: Schnabel A, Meyer-Frießem CH, Reichl SU, Zahn PK, Pogatzki-Zahn EM. Is intraoperative dexmedetomidine a new option for postoperative pain treatment? A meta-analysis of randomized controlled trials. Pain. 2013 Jul;154(7):1140-9.
Organ System: Neurological
Science Area: Pharmacology / Medical Therapy
Article Type: Meta Analysis / Systematic Review
Study Size: 1420
Primary Endpoint(s): Postoperative pain, morphine consumption, adverse events
Findings: Intraoperative dexmedetomidine reduced postoperative pain, morphine consumption and opioid-related adverse events compared with placebo. The most common adverse event in the dexmedetomidine patients was intraoperative bradycardia. Comparison of intraoperative dexmedetomidine v. opioid was difficult due to limited studies.
Authors' Conclusions: Intraoperative dexmedetomidine reduces post-operative pain and is opioid sparing. Intraoperative bradycardia and hypotension are risks and thus dexmedetomidine should be used with caution.
Additional comments from Journal Gems contributors: Dexmedetomidine has proved useful in my practice at reducing opioid doses in those at risk of opioid adverse events (eg. obese, OSA). This study seems to support this practice.