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Point: should lactate clearance be substituted for central venous oxygen saturation as goals of early severe sepsis and septic shock therapy? Yes.
Chest 2011
http://www.ncbi.nlm.nih.gov/pubmed/22147817
https://doi.org/10.1378/chest.11-2560
Notes
Lactate SHOULD be used instead of ScvO2 (CVC) for GDT in severe sepsis / septic shock